- 专利标题： PROCESSES OF MAKING AND CRYSTALLINE FORMS OF A MDM2 INHIBITOR
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申请号： US15175798申请日： 2016-06-07
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公开(公告)号： US20160287570A1公开(公告)日： 2016-10-06
- 发明人: Matthew BIO , Sebastien CAILLE , Brian COCHRAN , Yuanqing FANG , Filisaty VOUNATSOS , Sarah WORTMAN
- 申请人： AMGEN INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 主分类号： A61K31/451
- IPC分类号： A61K31/451
摘要：
The present invention provides processes for making 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid as well as intermediates and processes for making the intermediates. Also provided are crystalline forms of the compound and the intermediates.
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