发明申请
- 专利标题: ANTI-TROP2 ANTIBODY-DRUG CONJUGATE
- 专利标题(中): 抗TRP2抗体药物结合
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申请号: US15187179申请日: 2016-06-20
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公开(公告)号: US20160297890A1公开(公告)日: 2016-10-13
- 发明人: Toshinori AGATSUMA , Shu TAKAHASHI , Jun HASEGAWA , Daisuke OKAJIMA , Hirofumi HAMADA , Miki YAMAGUCHI
- 申请人: DAIICHI SANKYO COMPANY, LIMITED , SAPPORO MEDICAL UNIVERSITY
- 申请人地址: JP Tokyo JP Sapporo-shi
- 专利权人: DAIICHI SANKYO COMPANY, LIMITED,SAPPORO MEDICAL UNIVERSITY
- 当前专利权人: DAIICHI SANKYO COMPANY, LIMITED,SAPPORO MEDICAL UNIVERSITY
- 当前专利权人地址: JP Tokyo JP Sapporo-shi
- 优先权: JP2013-267548 20131225
- 主分类号: C07K16/30
- IPC分类号: C07K16/30 ; A61K31/4745 ; A61K47/48
摘要:
It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La-(CH2)n2-C(═O)— wherein the anti-TROP2 antibody is connected to the terminal of L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2-C(═O)— moiety with the nitrogen atom of the amino group at position 1 as a connecting position.
公开/授权文献
- US09850312B2 Anti-TROP2 antibody-drug conjugate 公开/授权日:2017-12-26