Invention Application
US20160304504A1 CRYSTALLINE FORMS OF N-(4-((3-(2-AMINO-4-PYRIMIDINYL)-2-PYRIDINYL)OXY)PHENYL)-4-(4-METHYL -2-THIENYL)-1-PHTHALAZINAMINE SALTS AND USES THEREOF
审中-公开
N-（4 - （（3-（2-氨基-4-吡啶基）-2-吡啶基）氧基）苯基）-4-（4-甲基-2-苯乙基）-1-苯基]胺盐的结晶形式及其用途
- Patent Title: CRYSTALLINE FORMS OF N-(4-((3-(2-AMINO-4-PYRIMIDINYL)-2-PYRIDINYL)OXY)PHENYL)-4-(4-METHYL -2-THIENYL)-1-PHTHALAZINAMINE SALTS AND USES THEREOF
- Patent Title (中): N-（4 - （（3-（2-氨基-4-吡啶基）-2-吡啶基）氧基）苯基）-4-（4-甲基-2-苯乙基）-1-苯基]胺盐的结晶形式及其用途
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Application No.: US15101373Application Date: 2014-11-25
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Publication No.: US20160304504A1Publication Date: 2016-10-20
- Inventor: Mary CHAVES , Matthew BIO , Matthew PETERSON
- Applicant: AMGEN INC.
- International Application: PCT/US2014/067385 WO 20141125
- Main IPC: C07D409/14
- IPC: C07D409/14 ; C07C309/30 ; C07C309/04
Abstract:
The present invention relates to crystalline forms and co-crystal forms of pharmaceutically acceptable salts of the compound, N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine (AMG 900, and pharmaceutical compositions comprising said crystalline and co-crystal forms thereof. The invention further provides uses of the crystalline forms and compositions, to treat cancer, including various types of solid tumors and hematologic cancer including myeloma and leukemia.
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