发明申请
- 专利标题： INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIM CHANNEL
- 专利标题（中）： 肾脏外侧药物通道的抑制剂
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申请号： US15101467申请日： 2014-12-16
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公开(公告)号： US20160304515A1公开(公告)日： 2016-10-20
- 发明人: Harry Chobanian , Barbara Pio , Yan Guo , Fa-Xiang Ding , Shuzhi Dong , Shawn P. Walsh , Jinlong Jiang , Dooseop Kim
- 申请人： Harry CHOBANIAN , Barbara PIO , Yan GUO , Fa-Xiang DING , Shuzhi DONG , Shawn P. WALSH , Jinlong JIANG , Dooseop KIM , MERCK SHARP & DOHME CORP.
- 国际申请： PCT/US14/70441 WO 20141216
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K45/06 ; A61K31/55 ; C07D487/04 ; A61K31/4985 ; C07D498/04 ; A61K31/519 ; A61K31/437
摘要：
The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
公开/授权文献
- US10000484B2 Inhibitors of the renal outer medullary potassim channel 公开/授权日：2018-06-19
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