发明申请
US20160311813A1 THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS
有权
噻唑替代氨基酸作为分离型酪氨酸激酶抑制剂
- 专利标题： THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS
- 专利标题（中）： 噻唑替代氨基酸作为分离型酪氨酸激酶抑制剂
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申请号： US15105411申请日： 2014-12-15
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公开(公告)号： US20160311813A1公开(公告)日： 2016-10-27
- 发明人: Michelle R. Machacek , Eric T. Romeo , Alan B.. Nortrup , Michael D. Altman
- 申请人： Michelle R. MACHACEK , Eric T. ROMEO , Alan B. NORTHUP , Michael D. ALTMAN , MERCK SHARP & DOHME CORP.
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US14/70239 WO 20141215
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; A61K31/5377 ; A61K31/433 ; A61K31/427 ; A61K45/06
摘要：
The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R3, R5, R6, A, Cy and the subscripts r, s, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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