Invention Application
US20160318864A1 4-(PIPERRAZIN-1-YL)-PYRROLIDIN-2-ONE COMPOUNDS AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS
有权
4-（PIPERRAZIN-1-YL） - 吡咯烷-2-酮化合物作为单糖甘油脂（MAGL）抑制剂
- Patent Title: 4-(PIPERRAZIN-1-YL)-PYRROLIDIN-2-ONE COMPOUNDS AS MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS
- Patent Title (中): 4-（PIPERRAZIN-1-YL） - 吡咯烷-2-酮化合物作为单糖甘油脂（MAGL）抑制剂
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Application No.: US15108000Application Date: 2014-12-25
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Publication No.: US20160318864A1Publication Date: 2016-11-03
- Inventor: Tatsuki KOIKE , Makoto FUSHIMI , Jumpei AIDA , Shuhei IKEDA , Tomokazu KUSUMOTO , Hideyuki SUGIYAMA , Hidekazu TOKUHARA
- Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
- Priority: JP2013-269244 20131226
- International Application: PCT/JP2014/084752 WO 20141225
- Main IPC: C07D207/273
- IPC: C07D207/273 ; C07D403/12 ; C07D409/12 ; C07D401/12 ; C07D403/14 ; C07D417/14 ; C07D413/12 ; C07D471/04 ; C07D401/14 ; C07D417/12 ; C07D405/12
Abstract:
The present invention aims to provide a compound having an MAGL inhibitory action, and useful as a prophylactic or therapeutic agent for neurodegenerative diseases (e.g., Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis and the like), anxiety disorder, pain (e.g., inflammatory pain, carcinomatous pain, nervous pain and the like), epilepsy and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
Public/Granted literature
- US09624170B2 4-(piperrazin-1-yl)-pyrrolidin-2-one compounds as monoacylglycerol lipase (MAGL) inhibitors Public/Granted day:2017-04-18
Information query
IPC分类:
