Three dimensional structural frames and enclosures and related methods are disclosed herein. In an example embodiment, an enclosure includes a plurality of three dimensional structural frames and opposing wall portions interconnected by the plurality of three dimensional structural frames, where the wall portions include a plurality of uniform wall sections, where the wall sections include a wall panel portion, a top wall portion, and sidewall portions, where the sidewall portions of the plurality of wall sections are joined to form the wall portions, and where the plurality of three dimensional structural frames are attached to the top wall portions of the wall sections.