Provided are a method and device for processing interference, a network control unit and User Equipment (UE). The method includes that: downlink transmission parameter indication information of second UE of a second access node and/or a first access node is sent to first UE through a Physical Downlink Shared Channel (PDSCH), wherein the first UE performs Interference Cancellation (IC) processing according to the received downlink transmission parameter indication information. By the present disclosure, the problems of high signaling overhead and great delay during acquisition of IC information, required by an advanced receiver, of victim UE in the related art are solved, and the effects of reducing signaling overhead and improving system performance are further achieved.