Invention Application
US20160354482A1 PHARMACEUTICAL COMPOSITIONS COMPRISING MACROLIDE DIASTEREOMERS, METHODS OF THEIR SYNTHESIS AND THERAPEUTIC USES
审中-公开
包含大分子二异氰酸酯的药物组合物，其合成和治疗用途的方法
- Patent Title: PHARMACEUTICAL COMPOSITIONS COMPRISING MACROLIDE DIASTEREOMERS, METHODS OF THEIR SYNTHESIS AND THERAPEUTIC USES
- Patent Title (中): 包含大分子二异氰酸酯的药物组合物，其合成和治疗用途的方法
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Application No.: US14913965Application Date: 2014-08-26
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Publication No.: US20160354482A1Publication Date: 2016-12-08
- Inventor: Thomas NITTOLI , Nareshkumar F. JAIN , Thomas Patrick MARKOTAN
- Applicant: REGENERON PHARMACEUTICALS, INC.
- International Application: PCT/US2014/052757 WO 20140826
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C07D498/18 ; A61K45/06 ; A61K31/537
Abstract:
The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses.
Information query
