Invention Application
US20160355517A1 BICYCLIC HETEROARYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
有权
作为TRKA激酶抑制剂的双相异构尿素,硫脲,胍和氰基化合物
- Patent Title: BICYCLIC HETEROARYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS
- Patent Title (中): 作为TRKA激酶抑制剂的双相异构尿素,硫脲,胍和氰基化合物
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Application No.: US14442503Application Date: 2013-11-13
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Publication No.: US20160355517A1Publication Date: 2016-12-08
- Inventor: Shelley Allen , Barbara J. Brandhuber , Kevin Ronald Condroski , Lily Huang , Timothy Kercher , Shannon L. Winski
- Applicant: ARRAY BIOPHARMA INC.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- International Application: PCT/US2013/069886 WO 20131113
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; C07D403/12 ; C07D471/04

Abstract:
Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Public/Granted literature
- US09822118B2 Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors Public/Granted day:2017-11-21
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