Invention Application
US20160355521A1 BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN
审中-公开
双酚尿素,硫脲,胍和氰尿嘧啶化合物可用于治疗疼痛
- Patent Title: BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN
- Patent Title (中): 双酚尿素,硫脲,胍和氰尿嘧啶化合物可用于治疗疼痛
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Application No.: US14442609Application Date: 2013-11-13
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Publication No.: US20160355521A1Publication Date: 2016-12-08
- Inventor: Shelley Allen , Steven Wade Andrews , James F. Blake , Barbara J. Brandhuber , Julia Haas , Yutong Jiang , Timothy Kercher , Gabrielle R. Kolakowski , Allen A. Thomas , Shannon L. Winski
- Applicant: ARRAY BIOPHARMA INC.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- International Application: PCT/US2013/069951 WO 20131113
- Main IPC: C07D491/048
- IPC: C07D491/048 ; C07D231/56 ; C07D405/14 ; C07D405/12 ; C07D403/14 ; C07D471/08 ; C07D401/14 ; C07D231/52 ; C07D403/04 ; C07D401/04 ; C07D413/12 ; C07D409/14 ; C07D231/40 ; C07D401/12

Abstract:
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Public/Granted literature
- US10351575B2 Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain Public/Granted day:2019-07-16
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