A vehicle control system includes one or more processors configured to assign plural vehicles to different groups in one or more vehicle systems for travel along one or more routes. The one or more processors also are configured to determine trip plans for the different groups. The trip plans designate different operational settings of the vehicles in the different groups at different locations along one or more routes during movement of the one or more vehicle systems along the one or more routes. The one or more processors also are configured to modify one or more of the groups to which the vehicles are assigned or the operational settings for the vehicles in one or more of the vehicle systems based on a movement parameter of one or more of the vehicle systems. The trip plans for the different groups of the vehicles are interdependent upon each other.