Invention Application
- Patent Title: MACROCYCLES AS FACTOR XIA INHIBITORS
- Patent Title (中): MACROCYCLES作为因子XIA抑制剂
-
Application No.: US15246813Application Date: 2016-08-25
-
Publication No.: US20160362414A1Publication Date: 2016-12-15
- Inventor: Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
- Applicant: Bristol-Myers Squibb Company
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D487/14 ; C07D471/14 ; C07D498/04

Abstract:
The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US09745313B2 Macrocycles as factor XIa inhibitors Public/Granted day:2017-08-29
Information query