Systems and methods are provided that may be implemented to utilize multiple sensors to intelligently control RF transmit power and specific absorption rate (SAR) produced from a wireless-enabled information handling system platform in the presence of a detected nearby human body. The disclosed systems and methods may be implemented in one example to avoid the poor performance and user experience that results from a reduction in the information handling system platform radio transmit power when it is not necessary (due to false detection of a human body), or that results when the platform transmit power is reduced too much and/or too quickly when nearby proximity of an actual human body is detected.