Invention Application
US20170002350A1 TAILED MIRTRON EFFECTORS FOR RNAI-MEDIATED GENE SILENCING
审中-公开
用于RNAi介导的基因沉默的TAILED MIRTRON EFFECTOR
- Patent Title: TAILED MIRTRON EFFECTORS FOR RNAI-MEDIATED GENE SILENCING
- Patent Title (中): 用于RNAi介导的基因沉默的TAILED MIRTRON EFFECTOR
-
Application No.: US15100630Application Date: 2014-10-17
-
Publication No.: US20170002350A1Publication Date: 2017-01-05
- Inventor: Yiqi SEOW
- Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
- International Application: PCT/SG2014/000490 WO 20141017
- Main IPC: C12N15/113
- IPC: C12N15/113
Abstract:
The present invention relates to an isolated mirtron capable of binding a target nucleic acid, wherein the isolated mirtron comprises: a) a stem loop structure comprising a 5′ splice site, b) a tail sequence comprising a 3′ splice site and a polypyrimidine-comprising sequence, and c) a branch point sequence. Further, the present invention relates to vectors and pharmaceutical compositions comprising such mirtrons as well as methods of treating a disease comprising administering such pharmaceutical compositions.
Information query
IPC分类:
