Motor winding fault detection circuits and methods to detect motor winding faults are disclosed. An example fault detection circuit includes a positive sequence voltage calculator to calculate a positive sequence voltage value for a three-phase motor; a positive sequence current calculator to calculate a positive sequence current value for the three-phase motor; an interpolator to calculate an expected negative sequence voltage value based on the positive sequence voltage value, the positive sequence current value, and measured characteristics of the three-phase motor; a negative sequence voltage calculator to calculate a measured negative sequence voltage value for the three-phase motor; and a fault detector to detect that a winding fault exists in the three-phase motor when a difference between the expected negative sequence voltage value and the measured negative sequence voltage value satisfies a threshold.