A touch display substrate, including: a substrate including a display region and a non-display region; a plurality of common electrode blocks spaced apart from each other; a plurality of wirings; a vertical shift circuit including a plurality of cascaded vertical shift circuit units, and each of the plurality of vertical shift circuit units is connected with wirings corresponding to a column of common electrode blocks, and is configured to sequentially output touch driving signals to the column of common electrode blocks; and a controlling IC configured to output a touch driving signal to the vertical shift circuit; wherein, the plurality of common electrode blocks are divided into n groups of common electrode blocks by columns, and the controlling IC is configured to apply scan pulse signals with different frequencies to the groups of common electrode blocks in different touch scanning time periods.