Disclosed are a data transmission method and device for device to device (D2D) communication, the method comprising: determining D2D communication destinations corresponding to a user equipment (UE) of a transmitting end; allocating a corresponding resource for each D2D communication destination; according to the resource corresponding to each D2D communication destination, generating a medium access control protocol data unit (MAC PDU) corresponding to the D2D communication destinations, and transmitting the MAC PDUs using the resource corresponding to the D2D communication destinations. The present invention separately generates a MAC PDU for each D2D communication destination of a UE of a transmitting end, thus preventing the data from one device to different D2D communication destination devices from being multiplexed into one MAC PDU, further reducing header overhead of the MAC PDU and eliminating unnecessary blind detection of a device of a receiving end, thereby saving power.