Invention Application
US20170015750A1 HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETTA-KLOTHO, FGF RECEPTORS AND COMPLEXES THEREOF
审中-公开
人类抗原结合蛋白,其包含KLOTHO,FGF受体及其复合物
- Patent Title: HUMAN ANTIGEN BINDING PROTEINS THAT BIND BETTA-KLOTHO, FGF RECEPTORS AND COMPLEXES THEREOF
- Patent Title (中): 人类抗原结合蛋白,其包含KLOTHO,FGF受体及其复合物
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Application No.: US15280662Application Date: 2016-09-29
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Publication No.: US20170015750A1Publication Date: 2017-01-19
- Inventor: Shaw-Fen Sylvia HU , Ian Nevin FOLTZ , Chadwick Terence KING , Yang LI , Taruna Arora
- Applicant: AMGEN INC.
- Applicant Address: US CA THOUSAND OAKS
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA THOUSAND OAKS
- Main IPC: C07K16/28
- IPC: C07K16/28

Abstract:
The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.
Public/Granted literature
- US10570205B2 Human antigen binding proteins that bind β-Klotho, FGF receptors and complexes thereof Public/Granted day:2020-02-25
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