发明申请
US20170016074A1 Methods and Kits for Classifying Diffuse Large B-Cell Lymphomas (DLBCLs) Into GCB-DLBCLs or Into ABC-DLBCLs
审中-公开
将扩散型大B细胞淋巴瘤（DLBCL）分类到GCB-DLBCL或ABC-DLBCL中的方法和试剂盒
- 专利标题： Methods and Kits for Classifying Diffuse Large B-Cell Lymphomas (DLBCLs) Into GCB-DLBCLs or Into ABC-DLBCLs
- 专利标题（中）： 将扩散型大B细胞淋巴瘤（DLBCL）分类到GCB-DLBCL或ABC-DLBCL中的方法和试剂盒
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申请号： US15124580申请日： 2015-03-10
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公开(公告)号： US20170016074A1公开(公告)日： 2017-01-19
- 发明人: Fabrice Jardin , Philippe Ruminy , Sylvain Mareschal , Vinciane Marchand , Cristina Bagacean
- 申请人： INSERM (Institute National de la Sante et de la Research Medicale) , Universite de Rouen , Centre Henri Becquerel
- 优先权： EP14305350.2 20140311
- 国际申请： PCT/EP2015/054952 WO 20150310
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The present invention relates to a method for classifying a diffuse large B-cell lymphoma (DLBCL) of a subject into a GCB-DLBCL or into a ABC-DLBCL comprising the step of determining the expression level of 10 genes in a tumor tissue sample obtained from the subject by performing a Reverse Transcriptase Multiplex Ligation dependent Probe Amplification (RT-MLPA) assay wherein the 10 genes are NEK6, IRF4, IGHM, LMO2, FOXP1, TNFRSF9, BCL6, TNFRSF13B, CCND2 and MYBL1.
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