The present disclosure relates to a method and an apparatus for single-hand operation on a full screen of a smart device, which pertains to the field of computer technology. The method for single-hand operation on a full screen includes determining whether a single-hand operation mode is activated, displaying a cursor indicator on the screen of the smart device when the single-hand operation is activated, moving the cursor indicator based on a track generated by a sliding operation on the screen of the smart device, determining whether the cursor indicator is moved into a trigger region, and activating the trigger region to receive an instruction associated with a touch event on the screen when the cursor indicator is moved into the trigger region. The touch event locates outside the trigger region.