Invention Application
US20170029489A1 HUMAN MONOCLONAL ANTIBODY WITH SPECIFICITY FOR DENGUE VIRUS SEROTYPE 1 E PROTEIN AND USES THEREOF
审中-公开
人类单克隆抗体具有特异性的登革病毒丝氨酸蛋白1 E蛋白及其用途
- Patent Title: HUMAN MONOCLONAL ANTIBODY WITH SPECIFICITY FOR DENGUE VIRUS SEROTYPE 1 E PROTEIN AND USES THEREOF
- Patent Title (中): 人类单克隆抗体具有特异性的登革病毒丝氨酸蛋白1 E蛋白及其用途
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Application No.: US15170838Application Date: 2016-06-01
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Publication No.: US20170029489A1Publication Date: 2017-02-02
- Inventor: Paul Anthony Macary , Ee Ping Evelyn Teoh , Brendon John Hanson , En Wei Teo , Angeline Pei Chiew Lim , Mah Lee Mary Ng , Shee Mei Lok , Petra Eveliina Kukkaro
- Applicant: National University Of Singapore , DSO National Laboratories
- Main IPC: C07K16/10
- IPC: C07K16/10 ; A61K39/42 ; A61K45/06
Abstract:
Compositions and methods for the treatment or prevention of Dengue virus infection in a vertebrate subject are provided. In particular, human neutralizing monoclonal antibodies to Dengue virus isolated from EBV immortalized B cells derived from patients who have recovered from Dengue infection are disclosed. Methods are provided for administering such antibodies to a vertebrate subject in an amount effective to reduce, eliminate, or prevent relapse from infection.
Public/Granted literature
- US10294293B2 Human monoclonal antibody with specificity for dengue virus serotype 1 E protein and uses thereof Public/Granted day:2019-05-21
Information query
