利索-全球专利检索

  1. 登录
  2. 注册
发明申请
US20170037133A1 IMMUNE-CHECKPOINT INHIBITORS FOR USE IN THE TREATMENT OF BLOOD-BORNE CANCERS 审中-公开
用于治疗血液肿瘤的免疫检查点抑制剂

IMMUNE-CHECKPOINT INHIBITORS FOR USE IN THE TREATMENT OF BLOOD-BORNE CANCERS
摘要：
The present invention provides an inhibitor against CD112 (Nectin-2, PVRL2), CD155 (PVR), Galectin-9, TIM-3 and/or TIGIT for use in a method of treatment of a blood-borne cancer, in particular acute myeloid leukemia (AML). Moreover, the present invention provides a pharmaceutical composition comprising an inhibitor against CD112 (Nectin-2, PVRL2), CD155 (PVR), Galectin-9, TIM-3 and/or TIGIT and a CAR T cell. The present invention further provides a pharmaceutical composition comprising an inhibitor against CD112 (Nectin-2, PVRL2), CD155 (PVR), Galectin-9, TIM-3 and/or TIGIT and an antibody construct that is capable of engaging T cells.
摘要（中）：

本发明提供了用于治疗血源性癌症，特别是急性髓细胞的方法中用于CD112（Nectin-2，PVRL2），CD155（PVR），Galectin-9，TIM-3和/或TIGIT的抑制剂 白血病（AML）。 此外，本发明提供了包含抑制CD112（Nectin-2，PVRL2），CD155（PVR），Galectin-9，TIM-3和/或TIGIT和CART细胞的抑制剂的药物组合物。 本发明还提供了包含抗CD112（Nectin-2，PVRL2），CD155（PVR），Galectin-9，TIM-3和/或TIGIT的抑制剂和能够与T细胞接合的抗体构建体的药物组合物。

信息查询
Global Dossier Espacenet
0/0