A physiological data collection device obtains physiological data from a subject interface on a subject. The physiological data collection device includes a data connector such as a USB connector for connecting directly to a computer. When the physiological data collection device is connected to the computer, the physiological data is uploaded to a remote data processing center for computer-based analysis and review by a medical professional. A report can be provided to the subject based on the analysis and review. When the subject interface is physically connected to the physiological data collection device, the data connector is prevented from being connected to an external device such as the computer.