Invention Application
US20170044256A1 METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS
审中-公开
使用PD-1轴绑定拮抗剂和TIGIT抑制剂治疗癌症的方法
- Patent Title: METHODS OF TREATING CANCER USING PD-1 AXIS BINDING ANTAGONISTS AND TIGIT INHIBITORS
- Patent Title (中): 使用PD-1轴绑定拮抗剂和TIGIT抑制剂治疗癌症的方法
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Application No.: US15239569Application Date: 2016-08-17
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Publication No.: US20170044256A1Publication Date: 2017-02-16
- Inventor: Jane GROGAN , Robert J. JOHNSTON , Bryan IRVING , Jason HACKNEY , Xin YU , Dan EATON , Kristin BOWLES , Laetitia COMPS-AGRAR
- Applicant: Genentech, Inc.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; C07K16/30 ; A61K45/06
Abstract:
The present invention describes combination treatment comprising a PD-1 axis binding antagonist and an agent that decreases or inhibits TIGIT expression and/or activity and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer or chronic infection.
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