Apparatus and methods to manage data connections to multiple wireless networks in a wireless communication device supporting multiple subscriber identities via multiple subscriber identity modules (SIMs) are disclosed. A representative method includes detecting an application request to establish a data connection; obtaining a preference for prioritization of data connections for the multiple SIMs; and based on the preference, establishing the data connection with a wireless network associated with one of the multiple SIMs. In representative embodiments, the preference is based on a user specified or default prioritization of the multiple SIMs, an order of radio access technologies (RATs), one or more quality metrics, data rates supported, and/or availability of wireless local area networks for the data connections.