Implementations described herein relate to filtering content items from a set of eligible content items based on a device filter. A mobile application may be incompatible with one or more devices based on an operating system, an operating system version, hardware configurations of the one or more client devices, etc. To remove incompatible content items, a device filter can be generated by comparing a set of required features for the corresponding mobile application with data from a data structure identifying several known mobile devices and associated sets of features. The set of required features for the mobile application may include a minimum operating system version, one or more eligible countries, and/or one or more features of a mobile device. The device filter can include a set of identifiers for the known mobile devices that are incompatible with the mobile application based on the comparison.