Invention Application
US20170058045A1 METHODS, COMPOSITIONS AND KITS FOR CELL SPECIFIC MODULATION OF TARGET ANTIGENS
审中-公开
方法，组合物和用于细胞特异性调节靶抗原的试剂盒
- Patent Title: METHODS, COMPOSITIONS AND KITS FOR CELL SPECIFIC MODULATION OF TARGET ANTIGENS
- Patent Title (中): 方法，组合物和用于细胞特异性调节靶抗原的试剂盒
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Application No.: US15119986Application Date: 2015-02-20
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Publication No.: US20170058045A1Publication Date: 2017-03-02
- Inventor: Jesper GROMADA , Eric SMITH , Andrew MURPHY , Nicholas PAPADOPOULOS , Joel MARTIN , George YANCOPOULOS , Douglas MACDONALD , David BUCKLER
- Applicant: Regeneron Pharmaceuticals, Inc.
- International Application: PCT/US15/16737 WO 20150220
- Main IPC: C07K16/32
- IPC: C07K16/32 ; A61K39/395 ; C07K16/28
Abstract:
The present invention provides, inter alia, a method for cell-specific modulation of a target antigen. The method comprises contacting a target cell having the target antigen on the surface of the target cell with: (a) first multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C1), (ii) a target antigen binding domain (T1); and (b) a second multi-specific antigen-binding polypeptide comprising: (i) a cell-specific antigen binding domain (C2), (ii) a target antigen binding domain (T2); wherein C1 and C2 interact with the same cell-specific antigen, and the cell-specific antigen and the target antigen are on the same target cell. Pharmaceutical compositions and kits thereof are also included in the present invention.
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