发明申请
US20170065643A1 METHOD OF STEM CELL DELIVERY INTO THE BRAIN DURING CHRONIC DISEASE USING BLOOD BRAIN BARRIER PERMEABILIZERS
审中-公开
使用血脑膜阻滞剂治疗慢性疾病的干细胞移植到脑中的方法
- 专利标题： METHOD OF STEM CELL DELIVERY INTO THE BRAIN DURING CHRONIC DISEASE USING BLOOD BRAIN BARRIER PERMEABILIZERS
- 专利标题（中）： 使用血脑膜阻滞剂治疗慢性疾病的干细胞移植到脑中的方法
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申请号： US15257315申请日： 2016-09-06
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公开(公告)号： US20170065643A1公开(公告)日： 2017-03-09
- 发明人: Cesario Venturina Borlongan , Paul R. Sanberg
- 申请人： Cesario Venturina Borlongan , Paul R. Sanberg
- 申请人地址： US FL Tampa
- 专利权人： University of South Florida
- 当前专利权人： University of South Florida
- 当前专利权人地址： US FL Tampa
- 主分类号： A61K35/51
- IPC分类号： A61K35/51 ; A61K47/26
摘要：
Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate the entry of stem cells from the periphery to the stroke brain. It is unknown whether BBB permeation in the chronic stage of the disease still facilitates the entry of stem cells from the periphery to the injured brain. Evidence herein shows BBB permeation in the chronic stage of stroke assisted in the entry of stem cells from the periphery to the stroke brain. Stroke models treated with human umbilical cord stem cells (hUCBC) only (2 million viable cells), mannitol or a combination. Results revealed that hUCBC alone or combined with mannitol displayed significant behavioral and histological deficits compared to control animals, with the HUCBC-mannitol combined treatment showing improvements over hUCBC only treatments in brain cell survival in the peri-infarct area. BBB permeation in chronic stroke also lowers the effective stem cell dose necessary to improve functional outcomes.
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