The present invention provides a wrench with translational wrench jaw comprising a first wrench jaw, a first handle and a connection portion, the connecting portion being arranged with a long hole, the long hole being provided with a first flank and a second flank which are parallel to each other, and the first flank being arranged with teeth; a second handle, connected with the connecting portion via a claw arranged in the long hole, the first end of the second handle being arranged with a cam; a second wrench jaw, connected with the connecting portion in a sliding manner, the second wrench jaw being arranged with a recess to accommodate the cam; a first connecting rod, connected with the first handle, a first end of the first connecting rod being arranged with an elastic component; a second connecting rod, connected with the second handle, a first end of the second connecting rod being arranged with an elastic component, the second end of the first connecting rod being connected with the second end of the second connecting rod. The wrench with translational wrench jaw provided by the present invention is suitable for gripping various workpieces; adopting two-stage transmission can provide greater gripping force, being more efficient and avoiding structural damage, thus prolonging the service life; By adopting locking mechanism can release operator's hands and be more convenient.