Invention Application
US20170073423A1 METHOD OF ENGINEERING MULTI-INPUT SIGNAL SENSITIVE T CELL FOR IMMUNOTHERAPY
审中-公开
工程多用途信号敏感细胞免疫学方法
- Patent Title: METHOD OF ENGINEERING MULTI-INPUT SIGNAL SENSITIVE T CELL FOR IMMUNOTHERAPY
- Patent Title (中): 工程多用途信号敏感细胞免疫学方法
-
Application No.: US15106783Application Date: 2014-12-19
-
Publication No.: US20170073423A1Publication Date: 2017-03-16
- Inventor: Alexandre JUILLERAT , Claudia BERTONATI , Julien VALTON , Philippe DUCHATEAU , Laurent POIROT
- Applicant: CELLECTIS
- Applicant Address: FR Paris
- Assignee: CELLECTIS
- Current Assignee: CELLECTIS
- Current Assignee Address: FR Paris
- Priority: DKPA201370806 20131220
- International Application: PCT/EP2014/078876 WO 20141219
- Main IPC: C07K16/30
- IPC: C07K16/30 ; C07K16/28 ; C07K14/47
Abstract:
The present invention relates to a method to engineer immune cell for immunotherapy. In particular said immune cells are engineered with chimeric antigen receptors, which be activated by the combination of hypoxia and ligand extracellular binding as input signals. The invention also relates to new designed chimeric antigen receptors which are able to redirect immune cell specificity and reactivity toward a selected target exploiting the ligand-binding domain properties and the hypoxia condition. The present invention also relates to cells obtained by the present method, in particular T-cells, comprising said chimeric antigen receptors for use in cancer treatments.
Public/Granted literature
- US10239948B2 Method of engineering multi-input signal sensitive T cell for immunotherapy Public/Granted day:2019-03-26
Information query
