Apparatuses and techniques are disclosed herein that enable region-based cache management. In some aspects, a configuration for a region of cache memory is determined based on characteristics of information to be written to the cache memory. Based on the determined configuration, an address range of the cache memory is allocated to define the region within the cache memory. A cache policy is the applied to the allocated address range to control caching of the information written to the region of cache memory. By so doing, regions of cache memory and respective caching policies applied thereto can be optimized for a variety of information types or usages.