A microsurgical instrument, with a handle and a removably insertable engine block. The handle can be coupled with a work piece and includes a base body and, mounted in the base body, an input shaft for motorized actuation of at least one degree of freedom of the work piece. In addition, the handle has an engine interface, into which the engine block can be installed, and on which at least an electric contact and a mechanical coupling are situated, the mechanical coupling includes a claw coupling element that is non-rotatably connected with the input shaft and can be coupled with a corresponding claw coupling element of the engine block. In addition, the handle has an actuation element, with which a current flow through the electric contact of the engine interface can be activated and deactivated. The claw coupling element of the handle is mounted on the input shaft so that it can slide longitudinally.