- 专利标题: SYSTEMS AND METHODS FOR PREVENTING, MITIGATING, AND/OR TREATING DEMENTIA
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申请号: US15360637申请日: 2016-11-23
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公开(公告)号: US20170143934A1公开(公告)日: 2017-05-25
- 发明人: Li-Huei Tsai , Emery Brown , Hannah Iaccarino , Anthony James Martorell , Chinnakkaruppan Adaikkan
- 申请人: Li-Huei Tsai , Emery Brown , Hannah Iaccarino , Anthony James Martorell , Chinnakkaruppan Adaikkan
- 主分类号: A61M21/00
- IPC分类号: A61M21/00 ; A61H23/00 ; A61N5/06
摘要:
The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-β (Aβ) peptide, C-terminal fragment-β (β-CTF), β-secretase (BACE1), γ-secretase, neuroinflammation, and/or dementia (e.g., Alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 Hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (FS-PV) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.
公开/授权文献
- US10265497B2 Systems and methods for treating dementia 公开/授权日:2019-04-23