An interference cancellation method and device are disclosed. In a process of performing cell reestablishment or cell handover, for any interference cancellation parameter previously received from a network-side device, a user terminal can continue to apply the interference cancellation parameter to perform an interference cancellation operation according to a specified first interference cancellation parameter application rule or first instruction information delivered by the network-side device, or release or no longer apply the interference cancellation parameter. In this way, a currently existing problem that a user terminal cannot know how to process a previously received interference cancellation parameter in a process of performing cell reestablishment or cell handover can be resolved, and further, an objective of improving an interference cancellation effect can be achieved.