Systems and methods for transmitting and receiving resource blocks using OFDM-based signals are provided. The OFDM-based signal has a number of sub-bands, and employs a respective numerology in each sub-band. Each numerology has a respective subcarrier spacing and OFDM symbol duration. For a given receiver, content is mapped to resource blocks within an assigned one of the sub-bands, using the sub-carrier spacing of the sub-band.