A vacuum mixing device or system mixes polymethylmethacrylate bone cement from a monomer liquid and a cement powder. The device or system comprising at least one cartridge comprising an evacuable interior for mixing of the bone cement, a mixing device for mixing the content in the interior of the at least one cartridge, a receptacle for receiving a separate container containing the monomer liquid or comprising an integrated container containing the monomer liquid, an opening device, which is arranged in the region of the receptacle in a manner movable relative to the receptacle so that, by moving the opening device, a separate container arranged in the receptacle is openable by means of the opening device, or the opening device is arranged in the region of the integrated container in a manner movable relative to the integrated container so that, by moving the opening device, the integrated container is openable by means of the opening device, a vacuum pump, in which a movable vacuum plunger for generating a negative pressure is arranged and delimits a vacuum pump chamber of the vacuum pump, a pressure pump, in which a movable pump plunger for conveying a liquid is arranged and delimits a pressure pump chamber of the pressure pump, a connection line, and a fluid connection. The device or system further comprises an operating element that is operatable from outside, wherein, by means of the operating element, the vacuum plunger in the vacuum pump is movable manually, the pump plunger in the pressure pump is movable manually, the opening device is movable manually relative to the receptacle or relative to the integrated container, and the mixing device is movable manually in the interior of the cartridge.