An integrated system for sequencing a string of oligo-nucleotides is disclosed, the system includes a sequencer for sequencing a plurality of fragments of the string of oligo-nucleotides via identifying oligo-nucleotides of the fragments one by one and a processor for processing the identified oligo-nucleotides to determine the sequence of the string of oligo-nucleotides and to stop the sequencer from sequencing redundant fragments, where the sequencer and the processor operate in a cycle for each oligo-nucleotide of the fragments.