- 专利标题： ISOLATED DONOR MHC-DERIVED PEPTIDE AND USES THEREOF
-
申请号： US15300331申请日： 2015-04-01
-
公开(公告)号： US20170173125A1公开(公告)日： 2017-06-22
- 发明人: Carole GUILLONNEAU , Ignacio ANEGON , Elodie PICARDA
- 申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE , UNIVERSITÉ DE NANTES
- 申请人地址： FR Paris FR Nantes
- 专利权人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE,UNIVERSITÉ DE NANTES
- 当前专利权人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE,UNIVERSITÉ DE NANTES
- 当前专利权人地址： FR Paris FR Nantes
- 优先权： EP14163072.3 20140401
- 国际申请： PCT/EP2015/057258 WO 20150401
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; G01N33/569 ; A61K35/17 ; C07K14/74 ; C12N5/0783
摘要：
The invention relates to an peptide derived from a polymorphic region of donor MHC class II molecules which induces tolerance and thus prevents transplant rejection in a patient in need thereof. The invention relates to isolated peptide of length ranging between 11 and 16 amino acids comprising the amino acid sequence: SDVGEYR (SEQ ID NO: 1) or a function-conservative variant thereof for use as drug. The invention relates to an in vitro method for determining whether a transplanted patient is tolerant, comprising a step of determining the presence of CD8+CD45RClow Tregs in a biological sample obtained from said transplanted patient, wherein the presence of CD8+CD45RClow Tregs is indicative of tolerance.
公开/授权文献
- US10137181B2 Isolated donor MHC-derived peptide and uses thereof 公开/授权日：2018-11-27
信息查询
