- 专利标题: COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF MEK
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申请号: US15460633申请日: 2017-03-16
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公开(公告)号: US20170183348A1公开(公告)日: 2017-06-29
- 发明人: Mark Gary BOCK , Henrik MOEBITZ , Sunil Kumar Panigrahi , Ramulu PODDUTOORI , Susanta SAMAJDAR
- 申请人: NOVARTIS AG
- 优先权: IN2418/DEL/13 20130814; IN1686/DEL/14 20140624
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; A61K31/53 ; A61K31/513 ; A61K31/497 ; A61K31/506 ; A61K31/4745
摘要:
The present invention relates to compounds of formula I: in which n, R1, R2, R3a, R4 and R5 are defined in the Summary of the Invention; capable of inhibiting the activity of MEK. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of hyperproliferative diseases like cancer.
公开/授权文献
- US10011599B2 Compounds and compositions as inhibitors of MEK 公开/授权日:2018-07-03
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