Invention Application
- Patent Title: CpG REDUCED FACTOR VIII VARIANTS, COMPOSITIONS AND METHODS AND USES FOR TREATMENT OF HEMOSTASIS DISORDERS
-
Application No.: US15462660Application Date: 2017-03-17
-
Publication No.: US20170216408A1Publication Date: 2017-08-03
- Inventor: Xavier ANGUELA , Sam Hsien-I SHEN
- Applicant: SPARK THERAPEUTICS, INC.
- Applicant Address: US PA Philadelphia
- Assignee: SPARK THERAPEUTICS, INC.
- Current Assignee: SPARK THERAPEUTICS, INC.
- Current Assignee Address: US PA Philadelphia
- Main IPC: A61K38/37
- IPC: A61K38/37 ; A61K45/06 ; C07K14/755 ; A61K48/00 ; C12N15/86 ; C12N7/00
Abstract:
CpG reduced nucleic acid variants encoding FVIII protein and methods of use thereof are disclosed. In particular embodiments, CpG reduced nucleic acid variants encoding FVIII are expressed more efficiently by cells, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced expression and/or activity over wild-type Factor VIII proteins or are packaged more efficiently into viral vectors.
Public/Granted literature
- US11168124B2 CpG reduced factor VIII variants, compositions and methods and uses for treatment of hemostasis disorders Public/Granted day:2021-11-09
Information query
IPC分类:
