- 专利标题： Wnt Antagonists and Methods of Treatment and Screening
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申请号： US15406229申请日： 2017-01-13
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公开(公告)号： US20170218041A1公开(公告)日： 2017-08-03
- 发明人: Sanjeev H. SATYAL , Satyajit Sujit Kumar Mitra , Austin L. Gurney
- 申请人： OncoMed Pharmaceuticals, Inc.
- 专利权人： OncoMed Pharmaceuticals, Inc.
- 当前专利权人： OncoMed Pharmaceuticals, Inc.
- 主分类号： C07K14/705
- IPC分类号： C07K14/705
摘要：
The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such Wnt antagonists. In particular, the invention discloses soluble FZD, SFRP and Ror receptors and their use.