- 专利标题: BCMA AND CD3 BISPECIFIC T CELL ENGAGING ANTIBODY CONSTRUCTS
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申请号: US15422619申请日: 2017-02-02
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公开(公告)号: US20170218077A1公开(公告)日: 2017-08-03
- 发明人: Tobias Raum , Markus Münz , Johannes Brozy , Peter Kufer , Patrick Hoffmann , Matthias Friedrich , Benno Rattel , Pamela Bogner , Andreas Wolf , Cornelius Pompe
- 申请人: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
- 主分类号: C07K16/28
- IPC分类号: C07K16/28
摘要:
The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
公开/授权文献
- US10301391B2 BCMA and CD3 bispecific T cell engaging antibody constructs 公开/授权日:2019-05-28
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