A banknote distribution method, a banknote distribution device and financial self-service equipment are provided. The method includes: acquiring the sequences and the corresponding denominations of banknotes of a plurality of mixed banknote boxes wherein banknotes with a plurality of denominations are stored in a mixed mode in the mixed banknote boxes and taken or stored in a stack mode; acquiring the number and the denomination of banknotes of a plurality of single banknote boxes wherein banknotes with only one denomination are stored in the single banknote boxes; acquiring a current banknote distribution limit; obtaining a banknote distribution result according to preset banknote distribution rules and the banknote distribution limit; and outputting the banknotes according to the banknote distribution results.