发明申请
- 专利标题: GENETIC MARKERS FOR ENGRAFTMENT OF HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS
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申请号: US15433713申请日: 2017-02-15
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公开(公告)号: US20170240964A1公开(公告)日: 2017-08-24
- 发明人: Chuen Yan LEUNG , Jonathan CLARKE , Jiejia XU , Federica SANTORO , Makoto SAHARA , Kenneth R. CHIEN
- 申请人: Chuen Yan LEUNG , Jonathan CLARKE , Jiejia XU , Federica SANTORO , Makoto SAHARA , Kenneth R. CHIEN
- 主分类号: C12Q1/68
- IPC分类号: C12Q1/68 ; A61K35/34 ; C12N5/077
摘要:
The present invention provides genetic markers for identifying engraftable human cardiac ventricular progenitor cells. The engraftment markers of the invention include angiogenic markers and extracellular matrix markers. Human ventricular progenitor cells expressing these markers are capable of forming ventricular tissue in vivo that is vascularized and supported by an extracellular matrix. Methods of engrafting human cardiac ventricular progenitor cells by transplanting into a subject progenitor cells that express the engraftment markers are also provided.