Invention Application
- Patent Title: 19-NOR C3, 3-DISUBSTITUTED C21-N-PYRAZOLYL STEROIDS AND METHODS OF USE THEREOF
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Application No.: US15297845Application Date: 2016-10-19
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Publication No.: US20170246191A1Publication Date: 2017-08-31
- Inventor: Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro , Richard Thomas Beresis
- Applicant: SAGE THERAPEUTICS, INC.
- Priority: CNPCT/CN2013/074323 20130417
- Main IPC: A61K31/58
- IPC: A61K31/58 ; A61K31/573

Abstract:
Provided herein are 19-nor C3,3-disubstituted C21-pyrazolyl steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein , R1, R2, R3a, R3b, R4a, R4b, R5, R6, and R7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
Public/Granted literature
- US10172871B2 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof Public/Granted day:2019-01-08
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