- 专利标题： THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
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申请号： US15509989申请日： 2015-09-08
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公开(公告)号： US20170247391A1公开(公告)日： 2017-08-31
- 发明人: Jolanta Grembecka , Tomasz Cierpicki , Dmitry Borkin , Jonathan Pollock , Hongzhi Miao , Duxin Sun , Liansheng Li , Tao Wu , Jun Feng , Pingda Ren , Yi Liu
- 申请人： The Regents of the University of Michigan , Kura Oncology, Inc
- 国际申请： PCT/US15/48957 WO 20150908
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; C07D519/00 ; C07F9/6558
摘要：
The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but not limited to MLL1, MLL2 and MLL-fusion oncoproteins. Compounds of the disclosure may be used in methods for the treatment of a wide variety of cancers and other diseases associated with one or more of MLL1, MLL2, MLL fusion proteins, and menin.
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