Disclosed herein are systems and methods that are directed to non-contiguous channel bonding in wireless networks. Non-contiguous channels can refer to channels that are not adjacent to one another in the frequency domain. In one aspect, the non-contiguous channel bonding may support non-high efficiency (HE) physical layer convergence procedure protocol data unit (PPDU) communications. For example, non-high throughput (non-HT) devices, for example, legacy devices, can be supported using non-high throughput (non-HT) format frames. In one embodiment, this can include integration of non-contiguous channel bonding with multi-user (MU) request to send, clear to send (RTS/CTS) exchanges. In another embodiment, a trigger-initiated uplink (UL) PPDU can be supported with non-contiguous channel bonding.