Invention Application
- Patent Title: TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY
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Application No.: US15511973Application Date: 2015-09-17
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Publication No.: US20170260268A1Publication Date: 2017-09-14
- Inventor: Gregory Beatty , Boris Engels , Neeraja Idamakanti , Carl H. June , Andreas Loew , Michael Milone , Huijuan Song , Enxiu Wang , Qilong Wu
- Applicant: Gregory BEATTY , Boris ENGELS , Neeraja IDAMAKANTI , Carl H JUNE , Andreas LOEW , Michael C. MILONE , Huijuan SONG , Enxiu WANG , Qilong WU
- Priority: CNPCT/CN2014/086694 20140917; CNPCT/CN2014/090578 20141107
- International Application: PCT/US2015/050715 WO 20150917
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/725 ; C07K16/30 ; C12N5/0783 ; A61K35/17 ; C07K14/74 ; C07K14/705
Abstract:
The present invention provides compositions and methods for regulating the specificity and activity of immune effector cells for use in immunotherapy. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “NKR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
Public/Granted literature
- US10577417B2 Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy Public/Granted day:2020-03-03
Information query
