Methods and apparatus are described that facilitate transmission of data, particularly between two devices within an electronic apparatus. In particular, a preamble for transmission in a sequence of symbols over a multi-wire communications interface, such as a MIPI C-PHY interface, is constructed to include one or more symbols each having a single state transition symbols for signaling a particular calibration preamble from a transmitter to a receiver over the multi-wire communications interface. The preamble, having only single state transition symbols, improves reliability of decoding the symbols at a receiver, including reception and decoding without the use of a calibration clock.